Reacción #41796

Ecuación de reacción

2-Nitro-4-(3-pyrrolidinylpropoxy)phenylamine

{4-[2-methoxy-4-(methylamino)-5-nitrophenoxy](2-pyridyl)}-N-methylcarboxamide

EtOH

→

4-(3-Pyrrolidinylpropoxy)benzene-1,2-diamine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction vessel is repeatedly purged (×3) with nitrogen
2. 2
   FiltraciónThe product is filtered through a Celite plug
3. 3
   Lavadothe plug washed with 25 mL of EtOH
4. 4
   Otroto yield 2

Procedimiento

To a solution 2-Nitro-4-(3-pyrrolidinylpropoxy)phenylamine 1 in EtOH, Pd/C (0.1 eq) is added. The reaction vessel is repeatedly purged (×3) with nitrogen, and then stirred under a hydrogen atmosphere for 18 h. The product is filtered through a Celite plug, and the plug washed with 25 mL of EtOH, to yield 2. LCMS 236.2 Rt 0.94 min.

Fuente