Reacción #417952

Ecuación de reacción

dimethyl sulfone

sodium-bis-(trimethylsilyl)-amide

THF

2-bromo-6-fluoropyridine

→

2-Bromo-6-(1-methanesulfonyl-cyclopropyl)-pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction is quenched by the addition
2. 2
   ExtracciónNaCl solution and extracted with EtOAc
3. 3
   SecadoThe organic layer is dried over MgSO4
4. 4
   Filtraciónfiltered
5. 5
   Otrothe solvent is removed in vacuo

Procedimiento

Under inert gas atmosphere 28.4 mL (56.8 mmol) of a sodium-bis-(trimethylsilyl)-amide solution in THF (c=2 mol/L) are chilled to −17° C. and dropwise charged with 2.00 g (11.3 mmol) 2-bromo-6-fluoropyridine. Afterwards 2.14 g (22.7 mmol) dimethyl sulfone are added and the reaction mixture is stirred at −17° C. for 1 h. The reaction is quenched by the addition of aq. sat.NaCl solution and extracted with EtOAc. The organic layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

Fuente