Reacción #417951

Ecuación de reacción

4-bromo-5-fluoro-pyridin-2-ol

ethyliodide

→

4-Bromo-2-ethoxy-5-fluoro-pyridine

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction is quenched by the addition of water
2. 2
   workup.ADDITIONDCM is added
3. 3
   Filtraciónthe resulting mixture is filtered
4. 4
   Secadodried over MgSO4
5. 5
   Filtraciónfiltered again
6. 6
   Otrothe solvent is removed in vacuo

Procedimiento

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo.

Fuente