Reacción #417949

Ecuación de reacción

5-bromo-2-fluoropyridine

cyclopropane methanol

NaH

→

5-Bromo-2-cyclopropylmethoxy-pyridine

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture is stirred at r.t. over night
2. 2
   OtroThe reaction is quenched by the addition of water
3. 3
   Extracciónextracted with EtOAc
4. 4
   Secadodried over MgSO4
5. 5
   Filtraciónfiltered
6. 6
   Otrothe solvent is removed in vacuo
7. 7
   OtroThe crude product is purified by HPLC (MeOH/H2O/FA)

Procedimiento

0.49 g (6.82 mmol) cyclopropane methanol in 10 mL THF are charged with 0.42 g (11.4 mmol) NaH and the reaction mixture is stirred at r.t. for 20 min. Then 1.00 g (5.68 mmol) 5-bromo-2-fluoropyridine are added and the mixture is stirred at r.t. over night. The reaction is quenched by the addition of water and extracted with EtOAc. The organic layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by HPLC (MeOH/H2O/FA).

Fuente