Reacción #417946

Ecuación de reacción

2-bromo-2-fluoropyridine

(2,2-difluoro-ethyl)-methyl-amine hydrochloride

DIPEA

→

6-Bromo-N-(2,2-difluoroethyl)-N-methylpyridin-2-amine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction is quenched by the addition of water
2. 2
   Extracciónextracted with DCM
3. 3
   Secadolayers are dried over MgSO4
4. 4
   Filtraciónfiltered

Procedimiento

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

Fuente