Reacción #417943

ord-10572e9e42914c269065c8e47baaf881

Ecuación de reacción

C[C@H](N)c1ccc(Br)cc1
(S)-1-(4-bromophenyl)ethylamine
CC(=O)OC(C)=O
acetic anhydride
→
CC(=O)N[C@@H](C)c1ccc(Br)cc1
(S)—N-(1-(4-Bromophenyl)ethyl)acetamide

Reactantes

C[C@H](N)c1ccc(Br)cc1
(S)-1-(4-bromophenyl)ethylamine
CC(=O)OC(C)=O
acetic anhydride

Reactivos

Ninguno

Disolventes

ClCCl
DCM

Condiciones de reacción

Temperatura
25°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThen the cooling is removed
  2. 2
    LavadoAfterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
  3. 3
    Secadolayer is dried over MgSO4
  4. 4
    Filtraciónfiltered
  5. 5
    Otrothe solvent is removed in vacuo

Procedimiento

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08877741B2uspto-grants-2014_11