Reacción #417928

Ecuación de reacción

3-(2-Trifluoromethyl-phenylmethanesulfonylmethyl)-pyridine-2-carboxylic acid methyl ester

tetrahydrofurane

HCl

→

colourless crystals

Rendimiento 37.3%

6,6-Dioxo-7-(2-trifluoromethyl-phenyl)-5,6-dihydro-thiopyrano[4,3-b]pyridin-8-ol

Rendimiento 37.3%

Disolventes

ethylacetate cyclohexane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONdiluted with methylenehloride
2. 2
   Extracciónextracted
3. 3
   SecadoThe organic phase was dried with sodiumsulfate
4. 4
   Concentraciónconcentrated

Procedimiento

To a solution of 3-(2-Trifluoromethyl-phenylmethanesulfonylmethyl)-pyridine-2-carboxylic acid methyl ester (7.58 g, 19.6 mmol) in tetrahydrofurane (160 ml) potassium tert-butoxide (2.20 g, 19.57 mmol) was added at room temperature and stirring was continued for 3.5 h. 1M HCl was added, diluted with methylenehloride and extracted. The organic phase was dried with sodiumsulfate and concentrated. Chromatography over silica with ethylacetate/cyclohexane gave 2.50 g colourless crystals (7.32 mmol).

Fuente