Reacción #417917

Ecuación de reacción

(S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine

naphthalene

→

(3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine

Condiciones de reacción

Procedimiento

contacting the (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine with an activated naphthalene in a reaction mixture under conditions sufficient to produce (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine (Duloxetine) having the structure of formula (VIII); and (e) recovering the (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine from the reaction mixture.

Fuente