Reacción #41698

Ecuación de reacción

pyrazine-2-carboxylic acid

1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride

4-amino-2-fluoro-N-methoxy-N-methylbenzamide

→

compound

N-(3-fluoro-4-((N-methoxy-N-methylamino)carbonyl)phenyl)pyrazine-2-carboxamide

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction liquid
2. 2
   OtroPyridine was evaporated away under reduced pressure
3. 3
   workup.ADDITIONthe residue was diluted with ethyl acetate
4. 4
   Lavadowashed with water
5. 5
   Secadodried with anhydrous magnesium sulfate
6. 6
   OtroThe solvent was evaporated away under reduced pressure
7. 7
   Lavadothe resulting solid was washed with a mixed solvent of ethyl acetate and hexane

Procedimiento

2.56 g of pyrazine-2-carboxylic acid and 4.66 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (20 ml) solution of 3.7 g of 4-amino-2-fluoro-N-methoxy-N-methylbenzamide, and the reaction liquid was stirred at room temperature for 1 hour. Pyridine was evaporated away under reduced pressure, and the residue was diluted with ethyl acetate, washed with water, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting solid was washed with a mixed solvent of ethyl acetate and hexane to obtain the entitled compound as a pale yellow solid.

Fuente