Reacción #41696

Ecuación de reacción

N-methoxy-N-methylamine hydrochloride

1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride

2-fluoro-4-nitrobenzoic acid

→

compound

2-fluoro-N-methoxy-N-methylbenzamide

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction liquid
2. 2
   OtroPyridine was evaporated away under reduced pressure, and water
3. 3
   workup.ADDITIONwas added to it
4. 4
   FiltraciónThe resulting deposit was taken out through filtration
5. 5
   Lavadowashed with water
6. 6
   Otrodried

Procedimiento

5.79 g of N-methoxy-N-methylamine hydrochloride and 12.4 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (80 ml) suspension of 10 g of 2-fluoro-4-nitrobenzoic acid, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and water was added to it. The resulting deposit was taken out through filtration, washed with water, and dried to obtain the entitled compound as a pale yellow solid.

Fuente