Reacción #41647

ord-d23f453932ce467ab722914a811b2947

Ecuación de reacción

CCOC(=O)c1ccccc1Oc1cc2nc(-c3ccccn3)[nH]c2cc1Oc1ccc(S(C)(=O)=O)cc1
5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine
CCOC(=O)c1ccccc1Oc1cc2nc(-c3ccccn3)[nH]c2cc1Oc1ccc(S(C)(=O)=O)cc1
5-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole
CON(C)C(=O)[C@H]1CCCN1
(R)—N-methoxy-N-methylprolinamide
→
CON(C)C(=O)[C@H]1CCCN1c1cc2[nH]c(-c3ccccn3)nc2cc1Oc1ccc(S(C)(=O)=O)cc1
(2R)-1-(6-(4-Methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidine-2-carboxylic acid methoxy-methyl-amide

Reactantes

CCOC(=O)c1ccccc1Oc1cc2nc(-c3ccccn3)[nH]c2cc1Oc1ccc(S(C)(=O)=O)cc1
5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine
CCOC(=O)c1ccccc1Oc1cc2nc(-c3ccccn3)[nH]c2cc1Oc1ccc(S(C)(=O)=O)cc1
5-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole
CON(C)C(=O)[C@H]1CCCN1
(R)—N-methoxy-N-methylprolinamide

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe entitled compound was obtained in the same method as in Example 15 or in accordance with the method

Procedimiento

The entitled compound was obtained in the same method as in Example 15 or in accordance with the method or by combining it with an ordinary method but using 5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine obtained in Example 14, and (R)—N-methoxy-N-methylprolinamide.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07728025B2uspto-grants-2010_06