Reacción #41605

Ecuación de reacción

tin(II) chloride dihydrate

dimethylformamide

N-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamide

→

compound

5-benzyloxy-6-(2-fluorophenoxy)-2-pyrazin-2-yl-1H-benzimidazole

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction liquid
2. 2
   OtroThe reaction liquid
3. 3
   Lavadowashed with aqueous saturated sodium bicarbonate, water and saturated saline in order
4. 4
   Secadodried with anhydrous magnesium sulfate
5. 5
   OtroThe solvent was evaporated away under reduced pressure
6. 6
   Lavadothe resulting residue was washed with a mixed solvent of ethyl acetate and hexane

Procedimiento

3.72 g of tin(II) chloride dihydrate was added to a dimethylformamide (16 ml) suspension of 1.52 g of N-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamide, and the reaction liquid was stirred overnight at 80° C. The reaction liquid was diluted with ethyl acetate, washed with aqueous saturated sodium bicarbonate, water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was washed with a mixed solvent of ethyl acetate and hexane to obtain the entitled compound as a yellow solid.

Fuente