Reacción #415501

Ecuación de reacción

acetic anhydride

L-aspartic acid

propionic acid

phosphorous trichloride

→

L-aspartic acid anhydride hydrochloride

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONTo a suspension of 10 g
2. 2
   Otrois continued at that temperature for about 1 1/2 hours
3. 3
   workup.STIRRINGthe reaction mixture is stirred at room temperature for approximately 8 hours longer
4. 4
   OtroThe crystals which separate from the reaction mixture
5. 5
   Filtraciónare filtered
6. 6
   Lavadowashed with ether
7. 7
   Otrodried

Procedimiento

To a suspension of 10 g. of L-aspartic acid in 40 ml. of propionic acid is added, at room temperature with stirring, 3.8 g. of phosphorous trichloride and stirring is continued at that temperature for about 1 1/2 hours. At the end of that time, 5 g. of acetic anhydride is added and the reaction mixture is stirred at room temperature for approximately 8 hours longer. The crystals which separate from the reaction mixture are filtered, washed with ether and dried to afford L-aspartic acid anhydride hydrochloride.

Fuente