Reacción #415360

Ecuación de reacción

oxetane

N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide

→

3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONA mixture of 20 g
2. 2
   OtroThe solution is evaporated in vacuo
3. 3
   workup.DISSOLUTIONthe residue is dissolved in 50 ml
4. 4
   Filtraciónof acetonitrile and filtered
5. 5
   OtroUpon evaporation the desired product
6. 6
   Otrocrystallizes
7. 7
   OtroThe product may be recrystallized from acetonitrile

Procedimiento

A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.

Fuente