Reacción #41528

Ecuación de reacción

carbon disulfide

potassium hydroxide

ethanol

3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine

4-(4-Fluoro-phenoxy)-2-pyridin-2-yl-6-(pyridin-3-yloxy)-1H-benzimidazole

→

4-(4-fluoro-phenoxy)-6-(pyridin-3-yloxy)-1H-benzimidazole-2-thiol

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe reaction liquid
2. 2
   OtroThe reaction liquid
3. 3
   Lavadowashed with water and saturated saline in order
4. 4
   Secadodried with anhydrous magnesium sulfate
5. 5
   OtroThe solvent was evaporated away under reduced pressure
6. 6
   Otroto obtain the entitled compound

Procedimiento

0.06 ml of carbon disulfide and 54 mg of potassium hydroxide were added to an ethanol (2.0 ml) solution of 273 mg of 3-(4-fluoro-phenoxy)-5-(pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 68, and the reaction liquid was stirred overnight at 80° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound.

Fuente