Reacción #41517

ord-a703f6b1d4324e8d8b438d132506ebda

Ecuación de reacción

CN(C)C(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2Oc2ccccc2S(C)(=O)=O)cc1
4-(4-dimethylcarbamoyl-phenoxy)-5-(2-methanesulfonyl-phenoxy)-benzene-1,2-diamine
CN(C)C(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2Oc2ccccc2S(C)(=O)=O)cc1
5-(4-Dimethylcarbamoyl-phenoxy)-6-(2-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole
O=Cc1nccs1
thiazol-2-carboxaldehyde
→
CN(C)C(=O)c1ccc(Oc2cc3nc(-c4nccs4)[nH]c3cc2Oc2ccccc2S(C)(=O)=O)cc1
5-(4-Dimethylcarbamoyl-phenoxy)-6-(2-methanesulfonyl-phenoxy)-2-thiazol-2-yl-1H-benzimidazole

Reactantes

CN(C)C(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2Oc2ccccc2S(C)(=O)=O)cc1
4-(4-dimethylcarbamoyl-phenoxy)-5-(2-methanesulfonyl-phenoxy)-benzene-1,2-diamine
CN(C)C(=O)c1ccc(Oc2cc3nc(-c4ccccn4)[nH]c3cc2Oc2ccccc2S(C)(=O)=O)cc1
5-(4-Dimethylcarbamoyl-phenoxy)-6-(2-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole
O=Cc1nccs1
thiazol-2-carboxaldehyde

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe entitled compound was obtained in the same method as in Example 1 (step 4) or in accordance with the method

Procedimiento

The entitled compound was obtained in the same method as in Example 1 (step 4) or in accordance with the method or by combining it with an ordinary method but using 4-(4-dimethylcarbamoyl-phenoxy)-5-(2-methanesulfonyl-phenoxy)-benzene-1,2-diamine obtained in Example 20 and thiazol-2-carboxaldehyde.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07728025B2uspto-grants-2010_06