Reacción #41460

Ecuación de reacción

HCl

3-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

title compound

Rendimiento 98.0%

3-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

Rendimiento 98.0%

Disolventes

Water

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe beige-orange precipitate that formed
2. 2
   Otrowas collected by,
3. 3
   Filtraciónfiltration
4. 4
   Lavadowashed with water
5. 5
   Otrodried in vacuo

Procedimiento

3-hydrazinylbenzoic acid (1.52 g, 10 mmol)), 2-fluoro-5-iodobenzaldehyde (2.5 g, 10 mmol) and caesium carbonate (3.26 g, 10 mmol) were stirred in DMF (10 mL) at r.t. under argon atmosphere for 2.5 h. Water (40 mL) was added and the clear solution was acidified with aqueous HCl (1.7 M). The beige-orange precipitate that formed was collected by, filtration, washed with water and dried in vacuo to give the title compound (3.75 g, 98%).

Fuente