Reacción #41456

Ecuación de reacción

HCl

4-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

Rendimiento 98.1%

Disolventes

Water

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe light yellow precipitate that formed
2. 2
   Filtraciónwas collected by filtration
3. 3
   Lavadowashed with water
4. 4
   Otrodried in vacuo

Procedimiento

4-hydrazinylbenzoic acid (1.54 g, 10 mmol), 2-fluoro-5-iodobenzaldehyde (2.52 g, 10 mmol) and caesium carbonate (3.27 g, 10 mmol) was stirred in DMF (10 mL) at r.t. for 70 min. Water (40 mL) was then added and the clear solution was acidified with aqueous HCl (1.7 M). The light yellow precipitate that formed was collected by filtration, washed with water and dried in vacuo to give 4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (3.77 g, 98%)

Fuente