Reacción #412451

ord-dddbd88460c34fbe8f67b0a783044330

Ecuación de reacción

[Na+].[OH-]
sodium hydroxide
N[C@@H](CC(=O)O)C(=O)O
L-aspartic acid
C=C1CC(=O)O1
diketene
→
CC(=O)CC(=O)N[C@@H](CC(=O)[O-])C(=O)[O-].[Na+].[Na+]
Disodium N-acetoacetylaspartate

Reactantes

[Na+].[OH-]
sodium hydroxide
N[C@@H](CC(=O)O)C(=O)O
L-aspartic acid
C=C1CC(=O)O1
diketene

Reactivos

Ninguno

Disolventes

O
water

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Temperaturathe solution cooled to 0°-5° C
  2. 2
    workup.STIRRINGstirred at 0°-10° C. for an additional 2.5 hours
  3. 3
    Filtraciónfiltered
  4. 4
    OtroThe homogeneous solution was evaporated to dryness under vacuum at 35°-40° C

Procedimiento

8.1 parts of sodium hydroxide were dissolved in 100 parts by volume of water and the solution cooled to 0°-5° C. 13.3 parts of L-aspartic acid were added and stirred until all dissolved, then 15.8 parts by volume of diketene were added dropwise over 90 minutes, stirred at 0°-10° C. for an additional 2.5 hours, and filtered. The homogeneous solution was evaporated to dryness under vacuum at 35°-40° C. Disodium N-acetoacetylaspartate was obtained as a white foam.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04440677uspto-grants-1984_04