Reacción #41186

Ecuación de reacción

tert-butyl nitrite

acetic acid

5-amino-1-(3-methoxypropyl)-1H-pyrazole-4-carboxylic acid ethyl ester

hydrochloric acid

→

5-chloro-1-(3-methoxypropyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Rendimiento 30.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added over 10 minutes
2. 2
   ExtracciónThe aqueous layer was extracted with methylene chloride (2×100 mL)
3. 3
   Secadodried over anhydrous sodium sulfate
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated in vacuo
6. 6
   Otroto provide the crude material
7. 7
   OtroThe product was purified by column chromatography on silica gel (eluting with ethyl acetate/hexanes, 1:1)

Procedimiento

To a mixture of 5-amino-1-(3-methoxypropyl)-1H-pyrazole-4-carboxylic acid ethyl ester (5.22 g, 23.0 mmol) in dry acetonitrile (46 mL) was added anhydrous cuprous chloride (3.73 g, 37.7 mmol) and acetic acid (2.6 mL, 46.0 mmol). The mixture was cooled to 0° C. in an ice-water bath after which tert-butyl nitrite (4.9 mL, 36.8 mmol) was added over 10 minutes. The solution was allowed to warm to room temperature and stir for 4 h. To the solution was carefully added 6.0N hydrochloric acid (20 mL). The aqueous layer was extracted with methylene chloride (2×100 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to provide the crude material. The product was purified by column chromatography on silica gel (eluting with ethyl acetate/hexanes, 1:1) to provide 5-chloro-1-(3-methoxypropyl)-1H-pyrazole-4-carboxylic acid ethyl ester (1.71 g, 30%) as an orange oil. Mass spectrum: m/z: 247.3 (M+1).

Fuente