Reacción #411330

Ecuación de reacción

triethylamine

benzyl 4-hydroxybenzoate

n-tridecanoic chloride

→

benzyl 4-n-dodecylcarbonyloxybenzoate

Rendimiento 83.0%

Disolventes

toluene

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawhile cooling it with ice
2. 2
   workup.ADDITIONAfter finishing adding dropwise
3. 3
   Otrothe reaction
4. 4
   Filtraciónwere filtered off
5. 5
   Lavadowashed with water
6. 6
   workup.DISTILLATIONThen, toluene was distilled off under reduced pressure
7. 7
   Otrothe resultant residue was recrystallized from ethanol

Procedimiento

{circle around (1)}: A solvent comprising 1.1 g of triethylamine and 5 g of toluene was added dropwise to a mixture comprising 2.28 g of benzyl 4-hydroxybenzoate, 2.33 g of n-tridecanoic chloride and 15 g of toluene in 30 minutes while cooling it with ice. After finishing adding dropwise, the mixture was stirred at room temperature for 3 hours. After finishing the reaction, deposited salts were filtered off, and the filtrate was neutralized with ½ N hydrochloric acid and washed with water. Then, toluene was distilled off under reduced pressure, and the resultant residue was recrystallized from ethanol, whereby 3.52 g of benzyl 4-n-dodecylcarbonyloxybenzoate was obtained in the form of a colorless crystal.

Fuente