Reacción #40992

Ecuación de reacción

2,4-Dimethoxy-pyrimidine-5-boronic acid

2-chloro-5-iodopyridine

Na2CO3

PPh3

→

title compound

5-(6-Chloro-pyridin-3-yl)-2,4-dimethoxy-pyrimidine

Disolventes

n-PrOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 2.5 hours
2. 2
   OtroThe solvent was evaporated under vacuum
3. 3
   Otrothe crude was partitioned between water and DCM
4. 4
   SecadoThe organic phase was dried (Na2SO4)
5. 5
   Otroevaporated

Procedimiento

2,4-Dimethoxy-pyrimidine-5-boronic acid (1.14 g, 6.26 mmol) was dissolved in degassed n-PrOH (20 ml) and then 2-chloro-5-iodopyridine (1 g, 4.2 mmol), Na2CO3 (884 mg, 15.8 mmol), PPh3 (109 mg, 0.42 mmol) and Pd(OAc)2 (46 mg) were added. The suspension was stirred at reflux for 2.5 hours. The solvent was evaporated under vacuum and the crude was partitioned between water and DCM. The organic phase was dried (Na2SO4) and evaporated to give the title compound that was used in the next step without further purification (quantitative yield).

Fuente