Reacción #409682

Ecuación de reacción

2-4

Ethyl (2-Oxo-3-(3-(ethylendioxy)butyl)pyrrolidin-1-yl)acetate

p-TSA

acetone

→

2-5

Ethyl (2-Oxo-3-(3-oxobutyl)pyrrolidin-1-yl)acetate

Disolventes

EtOAc

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 1 hr
2. 2
   OtroThe cooled reaction mixture
3. 3
   Lavadowashed with sat. NaHCO3 and brine
4. 4
   Otrodried
5. 5
   Concentración(MgSO4), and concentration

Procedimiento

A solution of 2-4 (1.1 g, 3.9 mmol), p-TSA (5 mg) and acetone (50 mL) was heated at reflux for 1 hr. The cooled reaction mixture was diluted with EtOAc and then washed with sat. NaHCO3 and brine, dried (MgSO4), and concentration to afford 2-5 as a yellow oil.

Fuente