Reacción #409595

Ecuación de reacción

1-[4-(4-hydroxyphenyl)butyl]imidazole

4-chloromethyl-2-phenylthiazole

→

4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-phenylthiazole

Rendimiento 91.0%

Condiciones de reacción

Procedimiento

In substantially the same manner as in Working Example 72, 1-[4-(4-hydroxyphenyl)butyl]imidazole was allowed to react with 4-chloromethyl-2-phenylthiazole to give 4-[4-[4-(1-imidazolyl)butyl]phenoxymethyl]-2-phenylthiazole. The yield was 91%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 93-94° C.

Fuente