Reacción #40954

Ecuación de reacción

water

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione

K2CO3

1-bromo-4-chloro-butane

→

title compound

Rendimiento 98.0%

3-Benzoyl-1-(4-chloro-butyl)-5-iodo-1H-pyrimidine-2,4-dione

Rendimiento 98.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   Extracciónthe mixture was extracted with ethyl acetate
3. 3
   SecadoThe organic phase was dried (Na2SO4)
4. 4
   Filtraciónfiltered
5. 5
   Otroevaporated
6. 6
   Otrothe crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3)

Procedimiento

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione (Prep36, 2.5 g, 7.3 mmol), K2CO3 (1 g, 7.3 mmol) and 1-bromo-4-chloro-butane (2.10 mL, 18 mmol) were suspended in dry DMF (10 mL). After stirring the reaction at room temperature overnight, water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated; the crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3) to give the title compound as a white solid (3 g, 98% yield).

Fuente