Reacción #40944

Ecuación de reacción

1-(4-Hydroxy-butyl)-5-(3-methyl-thiophen-2-yl)-1H-pyrimidine-2,4-dione

Dess-Martin periodinane

Ethyl acetate

→

title compound

Rendimiento 98.0%

4-[5-(3-Methyl-thiophen-2-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-butyraldehyde

Rendimiento 98.0%

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothe solution washed with aqueous saturated Na2S2O3 (3 mL) and NaHCO3 (3 mL)
2. 2
   SecadoThe organic phase was dried (Na2SO4)
3. 3
   Otroevaporated

Procedimiento

1-(4-Hydroxy-butyl)-5-(3-methyl-thiophen-2-yl)-1H-pyrimidine-2,4-dione (Prep 31, 30 mg, 0.11 mmol) was dissolved in dry DCM (2 mL), the solution was cooled to 0° C. and Dess-Martin periodinane (113 mg, 0.26 mmol) was added portionwise under nitrogen. The mixture was stirred at room temperature for 1.5 hours. Ethyl acetate was added and the solution washed with aqueous saturated Na2S2O3 (3 mL) and NaHCO3 (3 mL). The organic phase was dried (Na2SO4) and evaporated to give 30 mg of the title compound that was used in the next step without further purification (98% yield).

Fuente