Reacción #40919

Ecuación de reacción

dimethylamine

1,4-dioxa-spiro-[4.5]decane-8-carbaldehyde

1,4-dioxa-spiro[4.5]decane-8-carbaldehyde

potassium cyanide

hydrochloric acid

→

Dimethylamino-(1,4-dioxa-spiro[4.5]dec-8-yl)-acetonitrile

Disolventes

methanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with diethyl ether (4×100 ml)
2. 2
   SecadoThe organic phase was dried over sodium sulfate
3. 3
   Concentraciónconcentrated by evaporation in vacuo
4. 4
   Otrothe product was obtained as a white solid

Procedimiento

40% aqueous dimethylamine solution (85 ml, 0.67 mole), 1,4-dioxa-spiro-[4.5]decane-8-carbaldehyde 5 (240 g, 0.141 mole) and potassium cyanide (22.05 g, 0.338 mole) were added while cooling with ice to a mixture of 4N hydrochloric acid (37 ml) and methanol (22 ml). The mixture was stirred for four days at room temperature and then, after adding water (80 ml), extracted with diethyl ether (4×100 ml). The organic phase was dried over sodium sulfate, concentrated by evaporation in vacuo, and the product was obtained as a white solid.

Fuente