Reacción #40917

Ecuación de reacción

diethyl ether

4-oxo-cyclohexanecarboxylic acid ethyl ester

ethylene glycol

p-toluenesulfonic acid

→

1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water, sodium hydrogen carbonate solution and sodium chloride solution
2. 2
   SecadoThe solution was dried (Na2SO4)
3. 3
   Concentraciónconcentrated by evaporation in vacuo
4. 4
   Otrothe remaining colorless liquid was processed further without purification

Procedimiento

4-oxo-cyclohexanecarboxylic acid ethyl ester (52.8 g, 0.31 mole, Merck, Order No. 814249), ethylene glycol (67.4 g, 1.08 mole) and p-toluenesulfonic acid (0.7 g) in toluene (160 ml) were stirred for 20 hours at RT, and the reaction solution was poured into diethyl ether (300 ml) and washed with water, sodium hydrogen carbonate solution and sodium chloride solution. The solution was dried (Na2SO4), concentrated by evaporation in vacuo, and the remaining colorless liquid was processed further without purification.

Fuente