Reacción #40910

Ecuación de reacción

2-Amino-3-nitrobenzamide

N-chlorosuccinimide

→

title compound

Rendimiento 84.0%

2-amino-5-chloro-3-nitrobenzamide

Rendimiento 84.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered
2. 2
   LavadoThe filter cake was washed with acetonitrile
3. 3
   Otrodried

Procedimiento

2-Amino-3-nitrobenzamide (4.0 g) in warm anhydrous acetonitrile (1.25 L) was treated with N-chlorosuccinimide (3.1 g) at 60° C. under nitrogen for 20 hours. The mixture was allowed to cool to room temperature and filtered. The filter cake was washed with acetonitrile and dried to provide the title compound (3.98 g, 84%). MS (DCI/NH3) m/z 216 (M+H)+.

Fuente