Reacción #409084

Ecuación de reacción

pyridine

p-toluene sulfonic acid

ethylvinyl ether

hydroxystyrene t-butoxycarbonylmethoxystyrene morpholinylcarbonylmethoxystyrene

→

hydroxystyrene ethoxyethoxystyrene t-butoxycarbonylmethoxystyrene morpholinylcarbonylmethoxystyrene

Disolventes

water

dimethyl formamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroso obtained from Synthesis example 3
2. 2
   OtroAfter reaction for 1 hour
3. 3
   Otroto obtain a white solid
4. 4
   OtroThe solid, so formed
5. 5
   Filtraciónwas filtered off
6. 6
   Lavadowashed with distilled water for dehydration
7. 7
   workup.DISSOLUTIONdissolved again in acetone
8. 8
   workup.ADDITIONThen, the reacting solution dropwise added into 5 L water for filtration
9. 9
   Lavadowashed, for dehydration
10. 10
    Otrodrying
11. 11
    OtroThus, a resin, so obtained

Procedimiento

50g of poly(hydroxystyrene/t-butoxycarbonylmethoxystyrene/morpholinylcarbonylmethoxystyrene) where 8.4% of hydroxy groups in polyhydroxystyrene was substituted into t-butoxycarbonylmethoxy group and 5% of hydroxy groups into morpholinylcarbonylmethoxy group, so obtained from Synthesis example 3, was dissolved in 500 ml dimethyl formamide. With the addition of p-toluene sulfonic acid in catalytic amount, the reacting mixture was stirred at 20° C., followed by the addition of ethylvinyl ether (14 g). After reaction for 1 hour, the mixture was neutralized with pyridine, followed by dropwise adding into 5 L water to obtain a white solid. The solid, so formed, was filtered off, washed with distilled water for dehydration and dissolved again in acetone. Then, the reacting solution dropwise added into 5 L water for filtration and washed, for dehydration and drying. Thus, a resin, so obtained, was 52g of poly(hydroxystyrene/ethoxyethoxystyrene/t-butoxycarbonylmethoxystyrene/morpholinocarbonyl lmethoxystyrene) having the weight average molecular weight of 14,400 as polystyrene, in which 16% of hydroxy groups in polyhydroxystyrene was substituted into ethoxyethoxy group, 8.4% of hydroxy groups into t-butoxycarbonylmethoxy group and 5% of hydroxy groups into morpholinylcarbonylmethoxy group.

Fuente