Reacción #40820

ord-36fda2b6e6234cea9f29b13440c68cbc

Ecuación de reacción

O=C([O-])c1ccccn1
pyridine-2-carboxylate
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccncc2)n1
Compound 49
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccncc2)n1
Ethyl 3-(4-Ethylphenyl)-[2,4′]-bipyridinyl-6-carboxylate
→
CCc1ccc(-c2ccc(C(=O)OC)nc2-c2ccncc2)cc1
title compound
CCc1ccc(-c2ccc(C(=O)OC)nc2-c2ccncc2)cc1
Methyl 5-(4-Ethylphenyl)-6-(pyridin-4-yl)pyridine-2-carboxylate

Reactantes

O=C([O-])c1ccccn1
pyridine-2-carboxylate
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccncc2)n1
Compound 49
CCOC(=O)c1ccc(-c2ccc(CC)cc2)c(-c2ccncc2)n1
Ethyl 3-(4-Ethylphenyl)-[2,4′]-bipyridinyl-6-carboxylate

Reactivos

O=S(=O)(O)O
H2SO4

Disolventes

CO
methanol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otrowere reacted

Procedimiento

Following General Procedure E, ethyl 5-(4-ethylphenyl)-6-(pyridine-4-yl)phenyl)pyridine-2-carboxylate (Compound 49, 48 mg, 0.14 mmol) and conc. H2SO4 (10 drops) in methanol were reacted to produce the title compound as a light yellow solid.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07728014B2uspto-grants-2010_06