Reacción #4074

ord-8b2fe1a99b9b4f7d9bf65ad29d804e7a

Ecuación de reacción

COc1ccc2cc([C@H](C)C(=O)O)ccc2c1
(S)-2-(6-methoxy-2-naphthyl)propionic acid
Cl
hydrogen chloride
→
COc1ccc2cc([C@H](C)C(=O)OCC(C)C)ccc2c1
isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate

Reactantes

COc1ccc2cc([C@H](C)C(=O)O)ccc2c1
(S)-2-(6-methoxy-2-naphthyl)propionic acid
Cl
hydrogen chloride

Reactivos

Ninguno

Disolventes

CC(C)CO
isobutyl alcohol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    workup.DISTILLATIONthe excess alcohol is distilled off in vacuo
  2. 2
    Otrothe residue is purified by chromatography

Procedimiento

A solution of 300 mg of (S)-2-(6-methoxy-2-naphthyl)propionic acid in 5 ml of isobutyl alcohol is saturated with hydrogen chloride. After 24 hours, the excess alcohol is distilled off in vacuo and the residue is purified by chromatography using an alumina substrate to yield isobutyl (S)-2-(6-methoxy-2-naphthyl)propionate.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04723033uspto-grants-1988_02