Reacción #40702

Ecuación de reacción

1-phenyl-5-methyl-2-pyridinone

Lawesson's reagent

→

1-phenyl-5-methyl-2-pyridinethione

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroReaction mixture
2. 2
   Otrowas evaporated
3. 3
   Otrothe target compound was isolated by column chromatography (20-30% ethyl acetate-hexane)
4. 4
   Otrofollowed by crystallization from methyl-tert-butyl ether

Procedimiento

1-phenyl-5-methyl-2-pyridinone (555.7 mg, 3 mmol) was reacted with Lawesson's reagent (606.7 mg, 1.5 mmol) in toluene (5 ml) at 90° C. Reaction mixture was evaporated and the target compound was isolated by column chromatography (20-30% ethyl acetate-hexane) followed by crystallization from methyl-tert-butyl ether. Yield 403 mg (67%), yellow solid. The 1H NMR spectra was consistent with the structure of Compound 18.

Fuente