Reacción #40684

Ecuación de reacción

compound

t-butyl (1S)-2-chloro-1-methylethylcarbamate

3-fluorophenol

potassium carbonate

DMF

→

title compound

t-butyl (1S)-2-(3-fluorophenoxy)-1-methylethylcarbamate

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoAfter washing with water
2. 2
   Secadothe organic layer was dried over anhydrous magnesium sulfate
3. 3
   OtroThe solvent was evaporated

Procedimiento

To the compound (500 mg) obtained in Step 3 were added 3-fluorophenol (84 μl), potassium carbonate (250 mg) and DMF (2 ml), and the mixture was stirred overnight at 95° C. The reaction mixture was diluted with ethyl acetate. After washing with water, the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound as a crude product.

Fuente