Reacción #40668

Ecuación de reacción

2e

2-(3,3-dimethylindolin-1-yl)benzenamine

benzoyl isothiocyanate

→

2f

Rendimiento 112.7%

1-benzoyl-3-(2-(3,3-dimethylindolin-1-yl)phenyl)thiourea

Rendimiento 112.7%

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 2.5 h
2. 2
   FiltraciónThe reaction mixture was filtered through a cake of Celite®
3. 3
   Lavadowashed the cake with CH2Cl2
4. 4
   OtroThe solvent was evaporated under reduced pressure
5. 5
   OtroThe desired product was purified by column chromatography
6. 6
   Otroover 60 min
7. 7
   Lavadoas eluting gradient

Procedimiento

To a solution of 2e (40 mg, 0.168 mmol) in CH2Cl2 was added benzoyl isothiocyanate (30 mg, 0.189 mmol). The reaction mixture was kept at reflux for 2.5 h. The reaction mixture was filtered through a cake of Celite® and washed the cake with CH2Cl2. The solvent was evaporated under reduced pressure. The desired product was purified by column chromatography using 0 to 80% EtOAc in hexane over 60 min as eluting gradient to afford 2f (76 mg, 99%) as a powder. MS (ES) m/z 402 [M+H]+.

Fuente