Reacción #40585

Ecuación de reacción

bromine

5-amino-2-methoxypyridine

sodium acetate

sodium thiosulfate

→

expected compound

3-Amino-2-bromo-6-methoxypyridine

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrois prepared
2. 2
   workup.STIRRINGThe reaction mixture is kept stirring for 30 minutes, at room temperature
3. 3
   OtroThe aqueous phase obtained
4. 4
   Extracciónis extracted twice with ethyl acetate
5. 5
   SecadoThe combined organic phases are dried over magnesium sulfate
6. 6
   Concentraciónconcentrated under reduced pressure

Procedimiento

A mixture of 1.83 g (14.7 mM) of 5-amino-2-methoxypyridine and 1.21 g (14.7 mM) of sodium acetate in 12 ml of acetic acid is prepared and 0.75 ml (14.7 mM) of bromine is added gently, with stirring and while maintaining at room temperature. The reaction mixture is kept stirring for 30 minutes, at room temperature, and 200 ml of saturated sodium thiosulfate solution are then added. The aqueous phase obtained is extracted twice with ethyl acetate. The combined organic phases are dried over magnesium sulfate and concentrated under reduced pressure. 3 g of the expected compound are obtained in the form of a violet-colored solid (quantitative yield).

Fuente