Reacción #40531

Ecuación de reacción

2-amino-3-nitro-benzoic acid methyl ester

bromine

→

title compound

Rendimiento 87.4%

2-Amino-5-bromo-3-nitro-benzoic acid methyl ester

Rendimiento 87.4%

Disolventes

acetic acid

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe precipitated yellow solid was collected by suction filtration
2. 2
   Otrodried

Procedimiento

To a solution of 2.23 g (10.4 mmol) of 2-amino-3-nitro-benzoic acid methyl ester in 12 mL of acetic acid was added dropwise over 5 minutes a solution of 0.53 mL (10.4 mmol, 1 eq) of bromine in 2 mL of acetic acid. The mixture was stirred at room temperature for 30 minutes and poured into 100 grams of ice. The precipitated yellow solid was collected by suction filtration and dried to afford 2.50 g (82%) of the title compound as a yellow solid. 1H NMR (CDCl3) δ 3.95 (s, 3H), 8.35 (br s, 2H), 8.6 (d, 1H).

Fuente