Reacción #40391

Ecuación de reacción

water

benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one

ethyl 4-[4-(2-amino-2-methylpropyl)phenoxy]butyrate

oxalic acid

→

ethyl 4-(4-{2-[2-(6-benzyloxy-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)2-hydroxyethylamino]-2-methylpropyl}phenoxy)butyrate

Disolventes

diethyl ether

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe solid precipitated
2. 2
   Filtraciónfiltered
3. 3
   Lavadowashed with diethyl ether

Procedimiento

1.20 g (3.36 mmol) of benzyloxy-8-(2-ethoxy-2-hydroxyacetyl)-4H-benzo[1,4]oxazin-3-one and 0.90 g (3.22 mmol) of ethyl 4-[4-(2-amino-2-methylpropyl)phenoxy]butyrate are reacted in the manner described for Example 8(d). The crude product is dissolved in 10 mL ethyl acetate and 10 mL water and combined with oxalic acid with stirring. The solution is diluted with diethyl ether and the solid precipitated is suction filtered and washed with diethyl ether. Yield: 1.20 g (54%, oxalate); melting point 223° C.-227° C.

Fuente