Reacción #40373

Ecuación de reacción

ammonium chloride

methylmagnesium bromide

1-(4-ethylphenyl)propan-2-one

→

1-(4-ethylphenyl)-2-methylpropan-2-ol

Disolventes

diethyl ether

diethyl ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawhile being cooled with an ice bath in such a way that the temperature
2. 2
   Otrodoes not exceed 30° C
3. 3
   workup.ADDITIONAfter the addition
4. 4
   Temperaturathe reaction mixture is refluxed for 1.5 hours
5. 5
   OtroAfter the removal of the organic phase
6. 6
   Extracciónthe aqueous phase is extracted with diethyl ether
7. 7
   LavadoThe combined ether phases are washed with water
8. 8
   Secadodried with sodium sulfate
9. 9
   Otroevaporated down
10. 10
    OtroThe oil thus obtained
11. 11
    Otrois further reacted directly

Procedimiento

14.8 g (90 mmol) of 1-(4-ethylphenyl)propan-2-one dissolved in diethyl ether is added dropwise to 39 mL of a 3 molar solution of methylmagnesium bromide in diethyl ether while being cooled with an ice bath in such a way that the temperature does not exceed 30° C. After the addition has ended, the reaction mixture is refluxed for 1.5 hours and then hydrolyzed with 10% ammonium chloride solution. After the removal of the organic phase, the aqueous phase is extracted with diethyl ether. The combined ether phases are washed with water, dried with sodium sulfate, and evaporated down. The oil thus obtained is further reacted directly. Yield: 15.5 g (90%).

Fuente