Reacción #4027

Ecuación de reacción

2-(p-methoxyphenyl)-5-octylpyridine

hydrobromic acid

water

→

2-(p-hydroxyphenyl)-5-octylpyridine

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe solution was heated for 15 hours
2. 2
   Temperaturaunder reflux
3. 3
   Extracciónthe organic layer was extracted with chloroform
4. 4
   LavadoAfter washing the
5. 5
   Extracciónextract three times with water
6. 6
   Otrothe chloroform was removed by distillation
7. 7
   OtroThe residue was recrystallized from a mixture of acetone and hexane

Procedimiento

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

Fuente