Reacción #4017

Ecuación de reacción

2-chloro-1,1,1-triethoxyethane

2-aminothiophenol

→

2-chloromethylbenzothiazole

Rendimiento 91.3%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadothe resulting solution was washed with 3N HCl (10 ml)
2. 2
   OtroThe organic portion was evaporated
3. 3
   Otrothe residue chromatographed over silica gel

Procedimiento

A solution of 2-chloro-1,1,1-triethoxyethane (5.9 g) and 2-aminothiophenol (2.5 g) was heated at 80° C. for 15 minutes. After cooling to room temperature, it was dissovled in methylene chloride (30 ml) and the resulting solution was washed with 3N HCl (10 ml) and then with water (20 ml). The organic portion was evaporated and the residue chromatographed over silica gel to obtain 2-chloromethylbenzothiazole (3.35 g; 90% yield), m.p. 34° C.

Fuente