Reacción #4011

Ecuación de reacción

2-amino-4-chloro-6-chloromethylpyrimidine

→

2-amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride

Disolventes

diethyl ether

hydrogen chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas bubbled through the solution
2. 2
   Otroprecipitated the solid
3. 3
   Filtraciónwas filtered
4. 4
   Lavadowashed with ether
5. 5
   Otrodried in vacuo
6. 6
   OtroRecrystallisation from acetone

Procedimiento

3.56 Parts of 2-amino-4-chloro-6-chloromethylpyrimidine was dissolved in 53 parts of dry diethyl ether and dry hydrogen chloride was bubbled through the solution, with stirring, until no further solid precipitated the solid was filtered, washed with ether and dried in vacuo. Recrystallisation from acetone gave 2-amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride m.p. 145°-150° C. (decomposition).

Fuente