Reacción #3985

Ecuación de reacción

4-Amino-1-(naphth-2-ylmethyl)piperidine

benzoylisothiocyanate

→

1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was evaporated
2. 2
   workup.DISSOLUTIONthe gum dissolved in isopropyl alcohol
3. 3
   OtroThe solvent was evaporated
4. 4
   workup.DISSOLUTIONthe residue dissolved in ethyl acetate
5. 5
   OtroThe title compound crystallised
6. 6
   Filtraciónwas filtered
7. 7
   Secadodried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

Procedimiento

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoylisothiocyanate (0.69 g, 0.0042 m) in toluene (120 cm3) was stirred at room temperature for 6 hours. The solvent was evaporated and the gum dissolved in isopropyl alcohol and acidified with ethanolic HCl. The solvent was evaporated and the residue dissolved in ethyl acetate. The title compound crystallised and was filtered and dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

Fuente