Reacción #3982

Ecuación de reacción

Water

1-Chloromethylnaphthalene

4-benzoylureidopiperidine

triethylamine

→

1-Benzoyl-3-[1-(naphth-1-ylmethyl)piperid-4-yl]urea

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe precipitated solid filtered off
2. 2
   FiltraciónThe title compound was filtered off
3. 3
   Secadodried as the hydrochloride salt, hemihydrate (1.2 g), m.p. 185°-186° C.

Procedimiento

1-Chloromethylnaphthalene (0.88 g, 0.005 m), 4-benzoylureidopiperidine (1.28 g, 0.005 m) and triethylamine (0.6 g) in dimethylformamide (25 cm3) were stirred at room temperature for 24 hours. Water was added and the precipitated solid filtered off. The solid was suspended in isopropylalcohol and acidified with ethanolic HCl. The title compound was filtered off and dried as the hydrochloride salt, hemihydrate (1.2 g), m.p. 185°-186° C.

Fuente