Reacción #3968

Ecuación de reacción

2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine

hydrazine hydrate

→

2-(2-Methoxy-4-amino-5-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

Disolventes

isopropanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxed for 1.75 hours
2. 2
   ConcentraciónThe reaction mixture is concentrated by evaporation
3. 3
   Otrothe residue is triturated with 50 ml of ice water
4. 4
   Otrothe product precipitated
5. 5
   Otrois purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)]

Procedimiento

One half gram of 2-[2-methoxy-5-nitro-4-(4,4-dimethyl-7-nitro-2H,4H-isoquinolin-1,3-dione-2-yl)-phenyl]-5-methoxy-imidazo[4,5-b]pyridine is suspended in 10 ml of isopropanol, mixed with 0.5 ml of 80% hydrazine hydrate, and refluxed for 1.75 hours with stirring. The reaction mixture is concentrated by evaporation, the residue is triturated with 50 ml of ice water, and the product precipitated is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:2)].

Fuente