Reacción #3950

Ecuación de reacción

2-(2-dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

hydrochloric acid

→

2-(2-Dimethylamino-4-nitro-phenyl)-4H-imidazo[4,5-b]pyridin-5-one

Disolventes

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónneutralized, and extracted with ethyl acetate
2. 2
   LavadoAfter washing with water
3. 3
   Secadodrying with magnesium sulfate
4. 4
   Otrothe ethyl acetate phase is evaporated
5. 5
   OtroThe residue is crystallized by trituration in ether/petroleum ether

Procedimiento

A quantity of 0.2 gm of 2-(2-dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine is heated in a bomb tube to 100° C. for three hours with 5 ml of concentrated hydrochloric acid. The reaction mixture is poured onto about 20 ml of ice, neutralized, and extracted with ethyl acetate. After washing with water and drying with magnesium sulfate, the ethyl acetate phase is evaporated. The residue is crystallized by trituration in ether/petroleum ether.

Fuente