Reacción #3943

Ecuación de reacción

t-butyl isocyanate

3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride

triethylamine

→

N-(t-butyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride sesquihydrate

Rendimiento 140.2%

Disolventes

methylene chloride

Condiciones de reacción

Procedimiento

The procedure described in Example 2 was followed, using 0.8 g of t-butyl isocyanate, 3.0 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride, 1.6 g of triethylamine and 75 ml of methylene chloride, to give 2.2 g (60% of theory) of N-(t-butyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride sesquihydrate as a white crystalline solid, M.p. 246°-248° C.

Fuente