Reacción #3940

Ecuación de reacción

1-bromo-3-chloropropane

1-(4-chlorobenzyl)homopiperazine

potassium hydroxide

→

1-(4-chlorobenzyl)-4-(3-chloropropyl)homopiperazine

Rendimiento 42.0%

Disolventes

dimethyl sulfoxide

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroan additional 30 minutes
2. 2
   Otroat room temperature
3. 3
   Extracciónthe product was extracted with ether
4. 4
   Secadothe extract was dried (magnesium sulfate)
5. 5
   Concentraciónconcentrated in vacuo
6. 6
   OtroFinal purification
7. 7
   Otrothe solvent was removed in vacuo

Procedimiento

15.7 g of 1-bromo-3-chloropropane were added to a cooled solution of 15.0 g of 1-(4-chlorobenzyl)homopiperazine and 12.0 g of potassium hydroxide in 50 ml of dimethyl sulfoxide. The mixture was stirred at 5°-10° C. for one hour, and then an additional 30 minutes at room temperature. After the addition of ice water, the product was extracted with ether, and the extract was dried (magnesium sulfate) and concentrated in vacuo. Final purification was effected on a silica gel column (methylene chloride:methanol, 9:1), and the solvent was removed in vacuo to give 8.4 g (42% of theory) of 1-(4-chlorobenzyl)-4-(3-chloropropyl)homopiperazine as an oil.

Fuente