Reacción #3939

Ecuación de reacción

n-hexyl isocyanate

3-(4-cinnamylpiperazin-1-yl)propanethiol dihydrochloride

triethylamine

→

N-(n-hexyl)-S-[3-(4-cinnamylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride

Rendimiento 64.2%

Disolventes

methylene chloride

Condiciones de reacción

Procedimiento

The procedure described in Example 2 was followed, using 0.4 g of n-hexyl isocyanate, 1.0 g of 3-(4-cinnamylpiperazin-1-yl)propanethiol dihydrochloride, 0.6 g of triethylamine and 50 ml of methylene chloride, to give 0.44 g (31% of theory) of N-(n-hexyl)-S-[3-(4-cinnamylpiperazin-1-yl)propyl]thiocarbamate dihydrochloride as a white crystalline solid, M.p. 251°-253° C.

Fuente