Reacción #3928

Ecuación de reacción

1-(4-chlorobenzyl)piperazine

1-bromo-2-chloroethane

→

1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride

Rendimiento 112.0%

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 8 hours
2. 2
   OtroThe solvent was removed in vacuo, and 2N sodium hydroxide
3. 3
   workup.ADDITIONwas added to the residue
4. 4
   ExtracciónThe product was extracted with methylene chloride
5. 5
   Secadothe extract was dried (sodium sulfate)
6. 6
   Concentraciónconcentrated
7. 7
   OtroThe salt was precipitated with ethereal hydrochloric acid

Procedimiento

A mixture of 15.0 g of 1-(4-chlorobenzyl)piperazine, 14.4 g of 1-bromo-2-chloroethane and 150 ml of tetrahydrofuran was refluxed for 8 hours. The solvent was removed in vacuo, and 2N sodium hydroxide was added to the residue. The product was extracted with methylene chloride, and the extract was dried (sodium sulfate) and concentrated. The salt was precipitated with ethereal hydrochloric acid to give 13.8 g (56% of theory) of 1-(4-chlorobenzyl)-4-(2-chloroethyl)piperazine dihydrochloride as a white crystalline solid.

Fuente